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KMID : 0882419960510020227
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Korean Journal of Medicine
1996 Volume.51 No. 2 p.227 ~ p.233
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The Relationship between Serum beta-HCG Level, Amount of Urinary Excretion of HCG and Thyroid Fnction in Patients with Trophoblastic Disease
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김용태
조진아/박찬문/이선화/정호연/한이권/민헌기
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Abstract
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Objectives:
@EN It has been recognized that hyperthyroidism occur in patients with trophoblastic disease, either hydatidiform moles or choriocarcinoma. Recently, several lines of evidence have shown that human chorionic gonadotropin, secreted by the
trophoblastic
disease, is a thyroid stimulator and cause hyperthyroidism.
The study was undertaken to evaluate the incidence of hyperthyroidism in patients with trophoblastic disease and relationship between level of thyroid hormone and human chorionic gonadotropin.
@ES Methods:
@EN In 51 patients with hydatidiform mole and 13 patients with choriocarcinoma, we measured level of thyroid hormone, serum β-HCG and amount of urinary excretion of HCG.
@ES Results:
@EN 1) Hyperthyroidism was observed in 19.6% of the patients with hydatidiform mole and in 7.6% of the patients with choriocarcinoma.
2) The level of serum β-HCG and the amount of 24 hour urinary excretion of HCG in patients with hyperthyroidism were more than that in euthyroid patients.
3) The amount of 24 hour urinary excretion of HCG in patients with hydatidiform mole was more than that in choriocarcinoma patients.
4) The level of serum β-HCG and the amount of 24 hour urinary excretion of HCG had significant correlation with serum T3 and T4 levels but, the level of serum β-HCG had beteer correlation.
@HS Conclusion:
@HN The occurrence of hyperthyroidism is more frequent in patients with trophoblastic disease, and the degree of thyroid function is related with the level of serum β-HCG and urinary excretion of HCG, but, more closely related with serum β-HCG
level.
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